Cyclomodulins-harboring Escherichia coli isolated from obese and normal-weight subjects induces intestinal dysplasia in a mouse model

• Published in: World journal of microbiology & biotechnology Vol. 40; no. 12; p. 371
• Main Authors: DeLira-Bustillos, Nora, Angulo-Zamudio, Uriel A., Leon-Sicairos, Nidia, Flores-Villaseñor, Hector, Velazquez-Roman, Jorge, Tapia-Pastrana, Gabriela, Canizales-Quinteros, Samuel, Velázquez-Cruz, Rafael, Cortez-Hernández, Jesús Alberto, Canizalez-Roman, Adrian
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.12.2024; Springer Nature B.V
• Subjects: Animals; Applied Microbiology; Azoxymethane; Azoxymethane - toxicity; Biochemistry; Biomedical and Life Sciences; Biotechnology; blood; Body weight loss; Colorectal Neoplasms - microbiology; Colorectal Neoplasms - pathology; Damage assessment; Damage detection; Dextran; Dextran Sulfate; Dextrans; Diarrhea; Disease Models, Animal; Dysplasia; E coli; Environmental Engineering/Biotechnology; Escherichia coli; Escherichia coli - isolation & purification; Escherichia coli Infections - microbiology; Escherichia coli Proteins - genetics; Feces; Feces - microbiology; histology; Humans; Ileum; Ileum - microbiology; Ileum - pathology; Intestinal Polyps - microbiology; Intestinal Polyps - pathology; Intestine; Life Sciences; Male; Mice; Microbiology; Obesity; Obesity - complications; Obesity - microbiology; patients; Polyps; Risk factors; Small intestine; Sodium sulfate; Streptomycin; Weight loss; Normal-weight; Obesity; Cyclomodulins; and; Mouse mode; E. coli; Pks and cif

Recently, cyclomodulins have been identified in Escherichia coli ( E. coli ), which can induce dysplastic damage. This work aimed to determine the dysplastic activity of cyclomodulin-harboring E. coli isolated from CRC patients, obese and normal-weight subjects in a mouse model. Forty-two mice were...