YinYang1 deficiency ameliorates joint inflammation in a murine model of rheumatoid arthritis by modulating Th17 cell activation

• Published in: Immunology letters Vol. 197; pp. 63 - 69
• Main Authors: Kwon, Jeong-eun, Lee, Seon-Yeong, Seo, Hyeon-Beom, Moon, Young-Mee, Ryu, Jun-Geol, Jung, Kyung-Ah, Jhun, Joo-Yeon, Park, Jin-Sil, Hwang, Soo-Seok, Kim, Joo-Myeong, Lee, Gap Ryol, Park, Sung-Hwan, Cho, Mi-La
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2018
• Subjects: Rheumatoid arthritis; STAT3; Th17 cells; YY1; FLSs; H&E; STAT3; FACS; Th2 cells; IL-1β; IL-6; RA; YY1; IFN-γ; TNF-α; Rheumatoid arthritis; IL-17; Treg cells; CIA; PCR; Th17 cells

•YY1 as new target for RA therapies involved in Th17 cell differentiation. Yin Yang 1 (YY1) is a ubiquitously expressed transcription factor that functions in cooperation with various cofactors to regulate gene expression. In the immune system, YY1 enhances cytokine production and T helper (Th) 2 ef...