Treating Obstructive Sleep Apnea and Chronic Intermittent Hypoxia Improves the Severity of Nonalcoholic Fatty Liver Disease in Children

• Published in: The Journal of pediatrics Vol. 198; pp. 67 - 75.e1
• Main Authors: Sundaram, Shikha S., Halbower, Ann C., Klawitter, Jelena, Pan, Zhaoxing, Robbins, Kristen, Capocelli, Kelley E., Sokol, Ronald J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2018
• Subjects: Adolescent; Biomarkers - metabolism; Body Mass Index; Child; Chronic Disease; Cohort Studies; Continuous Positive Airway Pressure; CPAP; F-isoprostanes; F2-Isoprostanes - urine; Female; Humans; hypoxia; Hypoxia - complications; Hypoxia - therapy; Male; NASH; Non-alcoholic Fatty Liver Disease - complications; Non-alcoholic Fatty Liver Disease - therapy; Oxidative Stress; Pilot Projects; reactive oxygen species; Severity of Illness Index; sleep apnea; Sleep Apnea, Obstructive - complications; Sleep Apnea, Obstructive - therapy; CRP; hypoxia; NAS; AHI; AST; NAFLD; CPAP; ALT; NASH; ΔAHI; HDL; PDSS; SaO2; reactive oxygen species; sleep apnea; F-isoprostanes; BMI

To determine the effects of treating obstructive sleep apnea/nocturnal hypoxia on pediatric nonalcoholic fatty liver disease (NAFLD) severity and oxidative stress. Biopsy proven participants (n = 9) with NAFLD and obstructive sleep apnea/hypoxia were studied before and after treatment with continuou...