TRPC6 modulates adhesion of neutrophils to airway epithelial cells via NF-κB activation and ICAM-1 expression with ozone exposure

• Published in: Experimental cell research Vol. 377; no. 1-2; pp. 56 - 66
• Main Authors: Chen, Qing-Zi, Zhou, Yu-Bo, Zhou, Li-Fen, Fu, Zhao-Di, Wu, You-Sen, Chen, Yan, Li, Shu-Ni, Huang, Jian-Rong, Li, Jian-Hua
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.04.2019
• Subjects: Airway epithelial cells; Animals; Cell Adhesion; Epithelial Cells - drug effects; Epithelial Cells - physiology; Female; ICAM-1; Inflammation - chemically induced; Inflammation - pathology; Inflammation - prevention & control; Intercellular Adhesion Molecule-1 - genetics; Intercellular Adhesion Molecule-1 - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil adhesion; Neutrophils - drug effects; Neutrophils - physiology; NF-kappa B - genetics; NF-kappa B - metabolism; NF-κB; Ozone; Ozone - toxicity; Respiratory System - drug effects; Signal Transduction; TRPC6; TRPC6 Cation Channel - physiology; NF-κB; Ozone; Neutrophil adhesion; Airway epithelial cells; ICAM-1; TRPC6

Ozone (O3) is a major component of air pollution, which has been associated with airway inflammation characterized by the influx of neutrophils in asthmatic subjects. Canonical transient receptor potential 6 (TRPC6) channel is recently identified as a target of oxidative stress which is involved in...