A cross-sectional study comparing the expression of DNA repair molecules in subjects with and without atherosclerotic plaques

• Published in: Molecular biology reports Vol. 51; no. 1; p. 953
• Main Authors: Arapi, Berk, Unal, Selin, Malikova, Narmina, Omeroglu, Suat Nail, Guven, Mehmet
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.12.2024; Springer Nature B.V
• Subjects: 8-Hydroxy-2'-Deoxyguanosine - metabolism; 8-Hydroxydeoxyguanosine; Aged; Animal Anatomy; Animal Biochemistry; Arteriosclerosis; Atherosclerosis; Atherosclerosis - genetics; Atherosclerosis - metabolism; biomarkers; Biomedical and Life Sciences; blood serum; BRCA1 protein; Cardiovascular disease; Cardiovascular diseases; Carotid arteries; Carotid Arteries - metabolism; Carotid Arteries - pathology; Carotid artery; Carotid Artery Diseases - genetics; Carotid Artery Diseases - metabolism; Chromosome 3; Chromosome 5; Coronary artery disease; Coronary Artery Disease - genetics; Coronary Artery Disease - metabolism; Coronary vessels; Cross-Sectional Studies; Deoxyguanosine; DNA damage; DNA Damage - genetics; DNA repair; DNA Repair - genetics; Female; Gene expression; Gene Expression Regulation - genetics; genes; Heart diseases; Histology; Humans; Life Sciences; Male; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; miRNA; Morphology; Original Article; Plaque, Atherosclerotic - genetics; Plaque, Atherosclerotic - metabolism; Plaques; Polymerase chain reaction; quantitative polymerase chain reaction; Therapeutic targets; therapeutics; tumor suppressor proteins; Vein & artery diseases; APE1; Atherosclerotic plaques; ERCC2; miR-221-3p; BRCA1; miR-155-5p; miR-145-5p

Background Atherosclerosis, serving as the primary pathological mechanism at the core of cardiovascular disease, is now widely acknowledged to be associated with DNA damage and repair, contributing to atherosclerotic plaque formation. Therefore, molecules involved in the DNA repair process may play...