Physiological Risk Factors for Severe High-Altitude Illness A Prospective Cohort Study

• Published in: American journal of respiratory and critical care medicine Vol. 185; no. 2; pp. 192 - 198
• Main Authors: Richalet, Jean-Paul, Larmignat, Philippe, Poitrine, Eric, Letournel, Murielle, Canouï-Poitrine, Florence
• Format: Journal Article
• Language: English
• Published: New York, NY American Thoracic Society 15.01.2012
• Subjects: Acetazolamide - administration & dosage; Acute Disease; Adult; Altitude; Altitude Sickness - complications; Altitude Sickness - epidemiology; Altitude Sickness - etiology; Altitude Sickness - physiopathology; Altitude Sickness - prevention & control; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blood and lymphatic vessels; Brain Edema - epidemiology; Brain Edema - etiology; Brain Edema - physiopathology; Brain Edema - prevention & control; Cardiology. Vascular system; Cohort Studies; Confidence Intervals; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Diuretics - administration & dosage; Edema; Exercise; Exercise Test; Female; France - epidemiology; Headache - etiology; Humans; Hypertension, Pulmonary - epidemiology; Hypertension, Pulmonary - etiology; Hypertension, Pulmonary - physiopathology; Hypertension, Pulmonary - prevention & control; Hypoxia; Intensive care medicine; Male; Medical sciences; Middle Aged; Migraine; Mountain climbing; Odds Ratio; Oxygen saturation; Physical fitness; Physiology; Prospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; France; High altitude; Oxygen; Nervous system diseases; Intensive care; Environmental factor; Altitude induced disorder; Lung edema; Cerebral disorder; Acute mountain sickness; Cohort study; high-altitude cerebral edema; high-altitude pulmonary edema; Central nervous system disease; Risk factor; ventilatory response to hypoxia; Hypoxia; Cerebral edema; Resuscitation

An increasing number of persons, exposed to high altitude for leisure, sport, or work, may suffer from severe high-altitude illness. To assess, in a large cohort of subjects, the association between physiological parameters and the risk of altitude illness and their discrimination ability in a risk...