T cells, aging and senescence

• Published in: Experimental gerontology Vol. 134; p. 110887
• Main Authors: Pangrazzi, Luca, Weinberger, Birgit
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.06.2020
• Subjects: Aging; Senescence; T cells; Aging; T cells; Senescence

The T cell compartment undergoes characteristic changes with age, which contribute to increased incidence and severity of infections and reduced immunogenicity and efficacy of many vaccines in the older population. Production of naïve T cells is severely impaired due to a decreased output of lymphoi...