The GLP-1 receptor agonist liraglutide reverses mania-like alterations and memory deficits induced by D-amphetamine and augments lithium effects in mice: Relevance for bipolar disorder

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 99; p. 109872
• Main Authors: Chaves Filho, Adriano José Maia, Cunha, Natássia Lopes, de Souza, Alana Gomes, Soares, Michele Verde-Ramo, Jucá, Paloma Marinho, de Queiroz, Tatiana, Oliveira, João Victor Souza, Valvassori, Samira S., Barichello, Tatiana, Quevedo, Joao, de Lucena, David, Macedo, Danielle S.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 20.04.2020
• Subjects: Animals; Bipolar disorder; Bipolar Disorder - chemically induced; Bipolar Disorder - drug therapy; Bipolar Disorder - psychology; Brain-derived neurotrophic factor (BDNF); Cognitive impairment; D-amphetamine; Dextroamphetamine - toxicity; Drug Synergism; GLP-1; Glucagon-Like Peptide-1 Receptor - agonists; Lipid Peroxidation - drug effects; Lipid Peroxidation - physiology; Liraglutide; Liraglutide - administration & dosage; Lithium - administration & dosage; Male; Mania; Mania - chemically induced; Mania - drug therapy; Mania - psychology; Memory Disorders - chemically induced; Memory Disorders - drug therapy; Memory Disorders - psychology; Mice; Oxidative stress; Oxidative stress; GLP-1; Brain-derived neurotrophic factor (BDNF); Mania; Bipolar disorder; D-amphetamine; Liraglutide; Cognitive impairment

Metabolic and psychiatric disorders present a bidirectional relationship. GLP-1 system, known for its insulinotropic effects, has also been associated with numerous regulatory effects in cognitive and emotional processing. GLP-1 receptors (GLP-1R) agonists present neuroprotective and antidepressant/...