Optimizing the detection of N-nitrosamine mutagenicity in the Ames test - Heflich, Robert H.; Bishop, Michelle E.; Mittelstaedt, Roberta A.; Yan, Jian; Guerrero, Sharon K.; Sims, Audrey M.; Mitchell, Kamela; Moore, Nyosha; Li, Xilin; Mei, Nan; Elespuru, Rosalie K.; King, Sruthi T.; et al. (Regulatory toxicology and pharmacology, 2024)
Keywords: Acceptable intake limit; Activation, Metabolic; Ames test; Animals; Carcinogenic potency categorization approach; Cricetinae; Drug Contamination; Drug impurities; Escherichia coli - drug effects; Escherichia coli - genetics; Hamster liver S9; Liver - drug effects; Liver - metabolism; Male; Mutagenicity dose-response ranking; Mutagenicity Tests - methods; Mutagens - toxicity; Nitrosamine drug substance-related impurities; Nitrosamines - toxicity; Preincubation; Rat liver S9; Rats; Salmonella typhimurium - drug effects; Salmonella typhimurium - genetics; Small-molecule N-Nitrosamines; Drug impurities; Nitrosamine drug substance-related impurities; Hamster liver S9; Ames test; Mutagenicity dose-response ranking; Acceptable intake limit; Carcinogenic potency categorization approach; Preincubation; Rat liver S9; Small-molecule N-Nitrosamines