Cellular proliferation biases clonal lineage tracing and trajectory inference

• Published in: Bioinformatics (Oxford, England) Vol. 40; no. 8
• Main Authors: Bonham-Carter, Becca, Schiebinger, Geoffrey
• Format: Journal Article
• Language: English
• Published: England 02.08.2024
• Subjects: Single Cell; Lineage Tracing; Sampling; Statistics; Trajectory Inference

Lineage tracing and trajectory inference from single-cell RNA-sequencing data hold tremendous potential for uncovering the genetic programs driving development and disease. Single cell datasets are thought to provide an unbiased view on the diverse cellular architecture of tissues. Sampling bias, ho...