Neuro-protective roles of long non-coding RNA MALAT1 in Alzheimer's disease with the involvement of the microRNA-30b/CNR1 network and the following PI3K/AKT activation

• Published in: Experimental and molecular pathology Vol. 117; p. 104545
• Main Authors: Li, Li, Xu, Yuelong, Zhao, Meng, Gao, Zhiqiang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.12.2020
• Subjects: Alzheimer Disease - chemically induced; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid beta-Peptides - toxicity; Animals; Apoptosis - genetics; Cell Proliferation - genetics; CNR1; Humans; LncRNA MALAT1; MicroRNAs - genetics; miR-30b; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; Neuroprotective Agents - metabolism; Oncogene Protein v-akt - genetics; PC12 Cells; Phosphatidylinositol 3-Kinases - genetics; Phosphorylation; PI3K/AKT signaling pathway; Rats; Receptor, Cannabinoid, CB1 - genetics; RNA, Long Noncoding - genetics; Signal Transduction - genetics; miR-30b; CNR1; PI3K/AKT signaling pathway; Alzheimer's disease; LncRNA MALAT1

Long non-coding RNAs (lncRNAs) have been increasingly found to fulfill key functions in neurodegenerative diseases. This study aimed to probe the function of lncRNA MALAT1 in neuronal recovery in Alzheimer's disease (AD). Aβ25-35 was used to induce AD in a rat model and neuronal injury in PC12...