Regulation of progesterone signaling during pregnancy: Implications for the use of progestins for the prevention of preterm birth

• Published in: The Journal of steroid biochemistry and molecular biology Vol. 139; pp. 173 - 181
• Main Author: Byrns, Michael C.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2014
• Subjects: 17α-Hydroxyprogesterone caproate; Animals; Female; Gene Expression Regulation; Humans; Hydroxyprogesterones - therapeutic use; Metabolic Networks and Pathways; Molecular Targeted Therapy; Parturition; Pregnancy; Premature Birth - prevention & control; Progesterone - physiology; Progesterone metabolism; Progesterone receptor; Progestins - therapeutic use; Receptors, Progesterone - metabolism; Signal Transduction; Pregnancy; Parturition; Progesterone metabolism; Progesterone receptor; 17α-Hydroxyprogesterone caproate

► The pathways for maintaining progesterone signaling during pregnancy are examined. ► Progesterone synthesis and metabolism in target tissues plays an important role. ► Expression of nuclear and membrane progesterone receptors are also key determinants. ► Pharmacotherapy with progestins reduces the...