GLS1 promotes proliferation in hepatocellular carcinoma cells via AKT/GSK3β/CyclinD1 pathway

• Published in: Experimental cell research Vol. 381; no. 1; pp. 1 - 9
• Main Authors: Xi, Jianbo, Sun, Yaocheng, Zhang, Meiting, Fa, Zhenzhong, Wan, Yanya, Min, Zhenyu, Xu, Hong, Xu, Chengkai, Tang, Jianjun
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2019
• Subjects: AKT/GSK3β/CyclinD1 pathway; Animals; Benzophenanthridines - pharmacology; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor; Cell Proliferation; Cyclin D1 - metabolism; Disease Progression; Drug Delivery Systems; Female; Glutaminase - antagonists & inhibitors; Glutaminase - genetics; Glutaminase - metabolism; Glutaminase 1 (GLS1); Glycogen Synthase Kinase 3 beta - metabolism; Hepatocellular carcinoma (HCC); Humans; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Male; Mice; Mice, Nude; Middle Aged; Oncogenes; Proto-Oncogene Proteins c-akt - metabolism; Retrospective Studies; Signal Transduction; Up-Regulation; Cell proliferation; AKT/GSK3β/CyclinD1 pathway; Glutaminase 1 (GLS1); Hepatocellular carcinoma (HCC)

Glutamine metabolism is an important metabolic pathway for cancer cell survival, and there is a critical connection between tumor growth and glutamine metabolism. However, the role of GLS1 in hepatocellular carcinoma (HCC) progression remains to be elucidated. In this study, we reported that GLS1 ex...