Double stranded RNA in heterogeneous nuclear RNA from normal and chronic lymphocytic leukemic lymphocytes

Tritium labelled heterogeneous nuclear RNA (HnRNA) from normal and chronic lymphocytic leukemic (CLL) lymphocytes was investigated before and after fractionation into non-poly(A) containing (−HnRNA) and poly(A) containing (+HnRNA) HnRNA with respect to double stranded RNA (dsRNA). Statistically sign...

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Bibliographic Details
Published inCancer letters Vol. 4; no. 2; pp. 99 - 107
Main Authors Mnsson, Per Erik, Pero, Ronald W., Brandt, Lars
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.01.1978
Subjects
Humans
Leukemia, Lymphoid - analysis
Lymphocytes - analysis
Poly A - analysis
RNA - analysis
RNA, Neoplasm - analysis
dsRNA
chronic lymphocytic leukemic
CLL
white blood cell
messenger RNA
HnRNA
WBC
mRNA
heterogeneous nuclear RNA
double stranded RNA
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Abstract Tritium labelled heterogeneous nuclear RNA (HnRNA) from normal and chronic lymphocytic leukemic (CLL) lymphocytes was investigated before and after fractionation into non-poly(A) containing (−HnRNA) and poly(A) containing (+HnRNA) HnRNA with respect to double stranded RNA (dsRNA). Statistically significant higher amounts of rapidly labelled RNA were recovered from CLL lymphocytes when compared to normal cases. Within the CLL cases a significant linear correlation ( r = 0.95) was found between white blood cell counts and the amount of dsRNA in total HnRNA. After fractionation into (−) and (+) HnRNAs the ratios of dsRNAs, expressed as the dsRNA in (−) HnRNA divided by the dsRNA in (+) HnRNA, was lower than the corresponding values in normal cases for all the CLL cases except one. The relationship between (+) HnRNA and the total dsRNA level was different when comparing CLL and normal lymphocytes indicating a RNA processing abnormality.
AbstractList Tritium labelled heterogeneous nuclear RNA (HnRNA) from normal and chronic lymphocytic leukemic (CLL) lymphocytes was investigated before and after fractionation into non-poly(A) containing (−HnRNA) and poly(A) containing (+HnRNA) HnRNA with respect to double stranded RNA (dsRNA). Statistically significant higher amounts of rapidly labelled RNA were recovered from CLL lymphocytes when compared to normal cases. Within the CLL cases a significant linear correlation ( r = 0.95) was found between white blood cell counts and the amount of dsRNA in total HnRNA. After fractionation into (−) and (+) HnRNAs the ratios of dsRNAs, expressed as the dsRNA in (−) HnRNA divided by the dsRNA in (+) HnRNA, was lower than the corresponding values in normal cases for all the CLL cases except one. The relationship between (+) HnRNA and the total dsRNA level was different when comparing CLL and normal lymphocytes indicating a RNA processing abnormality.
Tritium labelled heterogeneous nuclear RNA (HnRNA) from normal and chronic lymphocytic leukemic (CLL) lymphocytes was investigated before and after fractionation into non-poly(A) containing (-HnRNA) and poly(A) containing (+HnRNA) HnRNA with respect to double stranded RNA (dsRNA). Statistically significant higher amounts of rapidly labelled RNA were recovered from CLL lymphocytes when compared to normal cases. Within the CLL cases a significant linear correlation (r = 0.95) was found between white blood cell counts and the amount of dsRNA in total HnRNA. After fractionation into (-) and (+) HnRNAs the ratios of dsRNAs, expressed as the dsRNA in (-) HnRNA divided by the dsRNA in (+) HnRNA, was lower than the corresponding values in normal cases for all the CLL cases except one. The relationship between (+) HnRNA and the total dsRNA level was different when comparing CLL and normal lymphocytes indicating a RNA processing abnormality.
Author Pero, Ronald W.
Brandt, Lars
Mnsson, Per Erik
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  organization: Department of Internal Medicine, University Hospital, Lund, (Sweden)
BackLink https://www.ncbi.nlm.nih.gov/pubmed/647656$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/0005-2787(73)90060-9
10.1111/j.1365-2141.1968.tb01496.x
10.1042/bj0960266
10.1016/0014-5793(72)80813-5
10.1111/j.1600-0609.1974.tb00211.x
10.1021/bi00761a005
10.1016/0005-2787(74)90219-6
10.1016/S0021-9258(19)44323-8
10.1111/j.1432-1033.1972.tb02527.x
10.1016/0092-8674(74)90154-8
10.1111/j.1600-0609.1975.tb00292.x
10.1007/BF00366256
10.1111/j.1600-0609.1976.tb01185.x
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Issue 2
Keywords dsRNA
chronic lymphocytic leukemic
CLL
white blood cell
messenger RNA
HnRNA
WBC
mRNA
heterogeneous nuclear RNA
double stranded RNA
Language English
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PublicationTitle Cancer letters
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References Silber, Unger, Ellman (bib17) 1968; 14
Burdon, Shenkin (bib1) 1972; 24
Molloy, Thomas, Darnell (bib9) 1972; 69
Kirby (bib4) 1965; 96
Kronenberg, Humpherys (bib5) 1972; 11
Lee, Mendecki, Brawerman (bib6) 1971; 68
Molloy, Jelinek, Salditt, Darnell (bib8) 1974; 1
Jelinek, Darnell (bib3) 1972; 69
Nakazato, Kopp, Edmonds (bib14) 1973; 248
Lindberg, Persson (bib7) 1972; 31
Mnsson, Holmouist, Deutsch, Nordén (bib12) 1975; 14
Edmonds, Vaughan, Nakazato (bib2) 1971; 68
Mnsson, Deutsch, Brandt (bib11) 1976; 17
Silber, Unger, Keller (bib18) 1965; 248
Ryskov, Tokarskaya, Georgiev (bib15) 1976; 2
Monckton, Naora (bib10) 1974; 335
Ryskov, Farashyan, Georgiev (bib16) 1972; 312
Mnsson, Deutsch, Nordén (bib13) 1974; 12
Lee (10.1016/S0304-3835(78)93742-4_bib6) 1971; 68
Mnsson (10.1016/S0304-3835(78)93742-4_bib11) 1976; 17
Lindberg (10.1016/S0304-3835(78)93742-4_bib7) 1972; 31
Mnsson (10.1016/S0304-3835(78)93742-4_bib12) 1975; 14
Silber (10.1016/S0304-3835(78)93742-4_bib18) 1965; 248
Monckton (10.1016/S0304-3835(78)93742-4_bib10) 1974; 335
Jelinek (10.1016/S0304-3835(78)93742-4_bib3) 1972; 69
Nakazato (10.1016/S0304-3835(78)93742-4_bib14) 1973; 248
Ryskov (10.1016/S0304-3835(78)93742-4_bib15) 1976; 2
Kirby (10.1016/S0304-3835(78)93742-4_bib4) 1965; 96
Molloy (10.1016/S0304-3835(78)93742-4_bib9) 1972; 69
Burdon (10.1016/S0304-3835(78)93742-4_bib1) 1972; 24
Molloy (10.1016/S0304-3835(78)93742-4_bib8) 1974; 1
Silber (10.1016/S0304-3835(78)93742-4_bib17) 1968; 14
Mnsson (10.1016/S0304-3835(78)93742-4_bib13) 1974; 12
Edmonds (10.1016/S0304-3835(78)93742-4_bib2) 1971; 68
Ryskov (10.1016/S0304-3835(78)93742-4_bib16) 1972; 312
Kronenberg (10.1016/S0304-3835(78)93742-4_bib5) 1972; 11
References_xml – volume: 14
  start-page: 42
  year: 1975
  end-page: 56
  ident: bib12
  article-title: heterogeneous nuclear RNA from lymphocytes of chronic lymphocytic leukemia: Adenylate-rich and double-stranded regions
  publication-title: Scand. J. Haematol.
  contributor:
    fullname: Nordén
– volume: 14
  start-page: 261
  year: 1968
  end-page: 272
  ident: bib17
  article-title: RNA metabolism in normal and leukemic leucocytes: Further studies on RNA synthesis
  publication-title: Br. J. Haematol.
  contributor:
    fullname: Ellman
– volume: 11
  start-page: 2020
  year: 1972
  end-page: 2026
  ident: bib5
  article-title: Double-stranded ribonucleic acid in sea urchin embryos
  publication-title: Biochemistry
  contributor:
    fullname: Humpherys
– volume: 69
  start-page: 3684
  year: 1972
  end-page: 3688
  ident: bib9
  article-title: Occurrence of uridylate-rich oligonucleotide regions in heterogeneous nuclear RNA of HeLa cells
  publication-title: Proc. Natl. Acad. Sci.
  contributor:
    fullname: Darnell
– volume: 335
  start-page: 139
  year: 1974
  end-page: 154
  ident: bib10
  article-title: Rat liver double-stranded RNA from nuclei and whole cells: Purification and characterization
  publication-title: Biochim. Biophys. Acta.
  contributor:
    fullname: Naora
– volume: 68
  start-page: 1331
  year: 1971
  end-page: 1335
  ident: bib6
  article-title: A polynucleotide segment rich in adenylic acid in the rapidly-labelled polyribosomal RNA component of mouse sarcoma 180 ascites cells
  publication-title: Proc. Natl. Acad. Sci.
  contributor:
    fullname: Brawerman
– volume: 248
  start-page: 1472
  year: 1973
  end-page: 1476
  ident: bib14
  article-title: Localisation of the polyadenylic sequences in messenger ribonucleic acid and in the heterogeneous nuclear ribonucleic acid of HeLa cells
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Edmonds
– volume: 17
  start-page: 276
  year: 1976
  end-page: 284
  ident: bib11
  article-title: Adenylate-rich sequences of heterogeneous nuclear RNA from normal and chronic lymphocytic leukemia lymphocytes
  publication-title: Scand. J. Haematol.
  contributor:
    fullname: Brandt
– volume: 248
  start-page: 1098
  year: 1965
  ident: bib18
  article-title: Synthesis and degradation of RNA by normal and leukemic leukocytes
  publication-title: J. Clin. Invest.
  contributor:
    fullname: Keller
– volume: 68
  start-page: 1336
  year: 1971
  end-page: 1340
  ident: bib2
  article-title: Polyadenylic acid sequences in the heterogeneous nuclear RNA and rapidly labelled polyribosomal RNA of HeLa cells: Possible evidence for a precursor relationship
  publication-title: Proc. Natl. Acad. Sci.
  contributor:
    fullname: Nakazato
– volume: 12
  start-page: 284
  year: 1974
  end-page: 290
  ident: bib13
  article-title: Ribonuclease inhibitor patterns in lymphocytes of chronic lymphocytic leukemia
  publication-title: Scand. J. Haematol.
  contributor:
    fullname: Nordén
– volume: 2
  start-page: 353
  year: 1976
  end-page: 361
  ident: bib15
  article-title: Direct demonstration of a complementarity between mRNA and double-stranded sequences of pre-mRNA
  publication-title: Mol. Biol. Rep.
  contributor:
    fullname: Georgiev
– volume: 1
  start-page: 43
  year: 1974
  end-page: 53
  ident: bib8
  article-title: Arrangement of specific oligonucleotides within poly(A) terminated HnRNA molecules
  publication-title: Cell
  contributor:
    fullname: Darnell
– volume: 96
  start-page: 266
  year: 1965
  end-page: 269
  ident: bib4
  article-title: Isolation and characterization of ribosomal ribonucleic acid
  publication-title: Biochem. J.
  contributor:
    fullname: Kirby
– volume: 24
  start-page: 11
  year: 1972
  end-page: 15
  ident: bib1
  article-title: Uridylate-rich sequences in rapidly labelled RNA of mammalian cells
  publication-title: FEBS Lett.
  contributor:
    fullname: Shenkin
– volume: 31
  start-page: 246
  year: 1972
  end-page: 254
  ident: bib7
  article-title: Isolation of mRNA from KB-cells by affinitychromatography on polyuricylicacid covalently linked to Sepharose
  publication-title: Eur. J. Biochem.
  contributor:
    fullname: Persson
– volume: 312
  start-page: 152
  year: 1972
  end-page: 164
  ident: bib16
  article-title: Double-helical regions in nuclear precursor of mRNA (pre-mRNA)
  publication-title: Biochim. Biophys. Acta
  contributor:
    fullname: Georgiev
– volume: 69
  start-page: 2537
  year: 1972
  end-page: 2541
  ident: bib3
  article-title: Double-stranded regions in heterogeneous nuclear RNA from HeLa cells
  publication-title: Proc. Natl. Acad. Sci.
  contributor:
    fullname: Darnell
– volume: 312
  start-page: 152
  year: 1972
  ident: 10.1016/S0304-3835(78)93742-4_bib16
  article-title: Double-helical regions in nuclear precursor of mRNA (pre-mRNA)
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/0005-2787(73)90060-9
  contributor:
    fullname: Ryskov
– volume: 14
  start-page: 261
  year: 1968
  ident: 10.1016/S0304-3835(78)93742-4_bib17
  article-title: RNA metabolism in normal and leukemic leucocytes: Further studies on RNA synthesis
  publication-title: Br. J. Haematol.
  doi: 10.1111/j.1365-2141.1968.tb01496.x
  contributor:
    fullname: Silber
– volume: 96
  start-page: 266
  year: 1965
  ident: 10.1016/S0304-3835(78)93742-4_bib4
  article-title: Isolation and characterization of ribosomal ribonucleic acid
  publication-title: Biochem. J.
  doi: 10.1042/bj0960266
  contributor:
    fullname: Kirby
– volume: 24
  start-page: 11
  year: 1972
  ident: 10.1016/S0304-3835(78)93742-4_bib1
  article-title: Uridylate-rich sequences in rapidly labelled RNA of mammalian cells
  publication-title: FEBS Lett.
  doi: 10.1016/0014-5793(72)80813-5
  contributor:
    fullname: Burdon
– volume: 69
  start-page: 3684
  year: 1972
  ident: 10.1016/S0304-3835(78)93742-4_bib9
  article-title: Occurrence of uridylate-rich oligonucleotide regions in heterogeneous nuclear RNA of HeLa cells
  contributor:
    fullname: Molloy
– volume: 12
  start-page: 284
  year: 1974
  ident: 10.1016/S0304-3835(78)93742-4_bib13
  article-title: Ribonuclease inhibitor patterns in lymphocytes of chronic lymphocytic leukemia
  publication-title: Scand. J. Haematol.
  doi: 10.1111/j.1600-0609.1974.tb00211.x
  contributor:
    fullname: Mnsson
– volume: 248
  start-page: 1098
  year: 1965
  ident: 10.1016/S0304-3835(78)93742-4_bib18
  article-title: Synthesis and degradation of RNA by normal and leukemic leukocytes
  publication-title: J. Clin. Invest.
  contributor:
    fullname: Silber
– volume: 11
  start-page: 2020
  year: 1972
  ident: 10.1016/S0304-3835(78)93742-4_bib5
  article-title: Double-stranded ribonucleic acid in sea urchin embryos
  publication-title: Biochemistry
  doi: 10.1021/bi00761a005
  contributor:
    fullname: Kronenberg
– volume: 335
  start-page: 139
  year: 1974
  ident: 10.1016/S0304-3835(78)93742-4_bib10
  article-title: Rat liver double-stranded RNA from nuclei and whole cells: Purification and characterization
  publication-title: Biochim. Biophys. Acta.
  doi: 10.1016/0005-2787(74)90219-6
  contributor:
    fullname: Monckton
– volume: 68
  start-page: 1336
  year: 1971
  ident: 10.1016/S0304-3835(78)93742-4_bib2
  article-title: Polyadenylic acid sequences in the heterogeneous nuclear RNA and rapidly labelled polyribosomal RNA of HeLa cells: Possible evidence for a precursor relationship
  contributor:
    fullname: Edmonds
– volume: 248
  start-page: 1472
  year: 1973
  ident: 10.1016/S0304-3835(78)93742-4_bib14
  article-title: Localisation of the polyadenylic sequences in messenger ribonucleic acid and in the heterogeneous nuclear ribonucleic acid of HeLa cells
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(19)44323-8
  contributor:
    fullname: Nakazato
– volume: 31
  start-page: 246
  year: 1972
  ident: 10.1016/S0304-3835(78)93742-4_bib7
  article-title: Isolation of mRNA from KB-cells by affinitychromatography on polyuricylicacid covalently linked to Sepharose
  publication-title: Eur. J. Biochem.
  doi: 10.1111/j.1432-1033.1972.tb02527.x
  contributor:
    fullname: Lindberg
– volume: 69
  start-page: 2537
  year: 1972
  ident: 10.1016/S0304-3835(78)93742-4_bib3
  article-title: Double-stranded regions in heterogeneous nuclear RNA from HeLa cells
  contributor:
    fullname: Jelinek
– volume: 1
  start-page: 43
  year: 1974
  ident: 10.1016/S0304-3835(78)93742-4_bib8
  article-title: Arrangement of specific oligonucleotides within poly(A) terminated HnRNA molecules
  publication-title: Cell
  doi: 10.1016/0092-8674(74)90154-8
  contributor:
    fullname: Molloy
– volume: 14
  start-page: 42
  year: 1975
  ident: 10.1016/S0304-3835(78)93742-4_bib12
  article-title: heterogeneous nuclear RNA from lymphocytes of chronic lymphocytic leukemia: Adenylate-rich and double-stranded regions
  publication-title: Scand. J. Haematol.
  doi: 10.1111/j.1600-0609.1975.tb00292.x
  contributor:
    fullname: Mnsson
– volume: 68
  start-page: 1331
  year: 1971
  ident: 10.1016/S0304-3835(78)93742-4_bib6
  article-title: A polynucleotide segment rich in adenylic acid in the rapidly-labelled polyribosomal RNA component of mouse sarcoma 180 ascites cells
  contributor:
    fullname: Lee
– volume: 2
  start-page: 353
  year: 1976
  ident: 10.1016/S0304-3835(78)93742-4_bib15
  article-title: Direct demonstration of a complementarity between mRNA and double-stranded sequences of pre-mRNA
  publication-title: Mol. Biol. Rep.
  doi: 10.1007/BF00366256
  contributor:
    fullname: Ryskov
– volume: 17
  start-page: 276
  year: 1976
  ident: 10.1016/S0304-3835(78)93742-4_bib11
  article-title: Adenylate-rich sequences of heterogeneous nuclear RNA from normal and chronic lymphocytic leukemia lymphocytes
  publication-title: Scand. J. Haematol.
  doi: 10.1111/j.1600-0609.1976.tb01185.x
  contributor:
    fullname: Mnsson
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Snippet Tritium labelled heterogeneous nuclear RNA (HnRNA) from normal and chronic lymphocytic leukemic (CLL) lymphocytes was investigated before and after...
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StartPage 99
SubjectTerms Humans
Leukemia, Lymphoid - analysis
Lymphocytes - analysis
Poly A - analysis
RNA - analysis
RNA, Neoplasm - analysis
Title Double stranded RNA in heterogeneous nuclear RNA from normal and chronic lymphocytic leukemic lymphocytes
URI https://dx.doi.org/10.1016/S0304-3835(78)93742-4
https://www.ncbi.nlm.nih.gov/pubmed/647656
https://search.proquest.com/docview/73987511
Volume 4
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