Unveiling genetic anchors in Saccharomyces cerevisiae: QTL mapping identifies IRA2 as a key player in ethanol tolerance and beyond

• Published in: Molecular genetics and genomics : MGG Vol. 299; no. 1; p. 103
• Main Authors: Tristão, Larissa Escalfi, de Sousa, Lara Isensee Saboya, de Oliveira Vargas, Beatriz, José, Juliana, Carazzolle, Marcelo Falsarella, Silva, Eduardo Menoti, Galhardo, Juliana Pimentel, Pereira, Gonçalo Amarante Guimarães, de Mello, Fellipe da Silveira Bezerra
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2024; Springer Nature B.V
• Subjects: Acetic acid; acid tolerance; alleles; Animal Genetics and Genomics; Biochemistry; bioethanol; Biofuels; Biomedical and Life Sciences; Chromosome Mapping; Drug tolerance; economic sustainability; Ethanol; Ethanol - metabolism; Ethanol - pharmacology; Fermentation; Fermentation - genetics; Gene frequency; Gene mapping; Genetic markers; genomics; GTPase-Activating Proteins; heat tolerance; Human Genetics; Industrial applications; Life Sciences; Microbial Genetics and Genomics; Missense mutation; mutation rate; Mutation, Missense; Original Article; oxygen; Plant Genetics and Genomics; Population genetics; Population studies; Quantitative Trait Loci; Saccharomyces cerevisiae; Saccharomyces cerevisiae - drug effects; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae Proteins - genetics; Strains (organisms); stress tolerance; sugars; Temperature tolerance; Yeast; yeasts; IRA2; Ethanol tolerance; QTL mapping

Ethanol stress in Saccharomyces cerevisiae is a well-studied phenomenon, but pinpointing specific genes or polymorphisms governing ethanol tolerance remains a subject of ongoing debate. Naturally found in sugar-rich environments, this yeast has evolved to withstand high ethanol concentrations, prima...