Novel oxazolo[4,5-g]quinazolin-2(1H)-ones: Dual inhibitors of EGFR and Src protein tyrosine kinases - Lin, Jinsheng; Shen, Wei; Xue, Jingwei; Sun, Juan; Zhang, Xue; Zhang, Can (European journal of medicinal chemistry, 2012)
Keywords: Anti-tumor agents; Biological and medical sciences; Cell Line, Tumor; Cell Proliferation - drug effects; Chemistry, Medicinal; EGFR inhibitor; Humans; Life Sciences & Biomedicine; Medical sciences; Miscellaneous; Molecular Docking Simulation; Oxazolo[4,5-g]quinazolin-2(1H)-one scaffold; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Protein Conformation; Protein Kinase Inhibitors - chemical synthesis; Protein Kinase Inhibitors - chemistry; Protein Kinase Inhibitors - metabolism; Protein Kinase Inhibitors - pharmacology; Protein tyrosine kinases (PTK); Quinazolines - chemical synthesis; Quinazolines - chemistry; Quinazolines - metabolism; Quinazolines - pharmacology; Receptor, Epidermal Growth Factor - antagonists & inhibitors; Receptor, Epidermal Growth Factor - chemistry; Receptor, Epidermal Growth Factor - metabolism; Science & Technology; Src inhibitor; src-Family Kinases - antagonists & inhibitors; src-Family Kinases - chemistry; src-Family Kinases - metabolism; Protein tyrosine kinases (PTK); Src inhibitor; Anti-tumor agents; Oxazolo[4,5-g]quinazolin-2(1H)-one scaffold; EGFR inhibitor; NNLYOFSWWFKIMS-UHFFFAOYSA-N; IRREVERSIBLE INHIBITORS; CANCER; GROWTH-FACTOR RECEPTOR; NEUTRAL 5-SUBSTITUTED 4-ANILINOQUINAZOLINES; POTENT; ORALLY-ACTIVE INHIBITORS; EXPRESSION; BINDING; Oxazolo[4,5-g]quinazolin-2(1H)-one; scaffold