N-glycosylation of CD4+ T cell changes with the development in Graves' disease and is sensitive to methimazole treatment

• Published in: Biochimica et biophysica acta. General subjects Vol. 1869; no. 8; p. 130824
• Main Authors: Trzos, Sara, Szewczyk, Marta, Link-Lenczowski, Paweł, Sokołowski, Grzegorz, Trofimiuk-Müldner, Małgorzata, Bocian, Katarzyna, Pocheć, Ewa
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2025
• Subjects: Adult; Antithyroid Agents - pharmacology; Antithyroid Agents - therapeutic use; Autoimmunity; CD4+ T cells; CD4-Positive T-Lymphocytes - drug effects; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - metabolism; Female; Glycosylation - drug effects; Glycosyltransferases; Graves Disease - drug therapy; Graves Disease - immunology; Graves Disease - metabolism; Graves Disease - pathology; Graves' disease; Humans; Male; Methimazole; Methimazole - pharmacology; Methimazole - therapeutic use; Middle Aged; N-glycosylation; Polysaccharides - metabolism; Autoimmunity; Methimazole; CD4+ T cells; Graves' disease; N-glycosylation; Glycosyltransferases; CD4(+) T cells

Graves' disease (GD) is one of the most common autoimmune disorders. Helper T (Th) cells, whose surface receptors are rich in glycans, are involved in the GD pathomechanism. N-glycosylation is altered during autoimmunity and can be modulated by pharmacotherapy. We hypothesized that changes in T...