Spatial profiling technologies illuminate the tumor microenvironment

• Published in: Cancer cell Vol. 41; no. 3; pp. 404 - 420
• Main Authors: Elhanani, Ofer, Ben-Uri, Raz, Keren, Leeat
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.03.2023
• Subjects: Humans; Immunotherapy - methods; multiplexed imaging; Neoplasms - therapy; Prognosis; spatial profiling; spatial transcriptomics; tumor microenvironment; Tumor Microenvironment - physiology; tumor microenvironment; multiplexed imaging; spatial profiling; spatial transcriptomics
• ISSN: 1535-6108; 1878-3686; 1878-3686
• DOI: 10.1016/j.ccell.2023.01.010

The tumor microenvironment (TME) is composed of many different cellular and acellular components that together drive tumor growth, invasion, metastasis, and response to therapies. Increasing realization of the significance of the TME in cancer biology has shifted cancer research from a cancer-centri...