IL-10 gene promoter and intron polymorphisms and changes in IL-10 secretion in women with idiopathic recurrent miscarriage

• Published in: Human reproduction (Oxford) Vol. 29; no. 5; pp. 1025 - 1034
• Main Authors: Qaddourah, R.H., Magdoud, K., Saldanha, F.L., Mahmood, N., Mustafa, F.E., Mahjoub, T., Almawi, W.Y.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.05.2014
• Subjects: Abortion, Habitual - genetics; Adult; Alleles; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Interleukin-10 - genetics; Interleukin-10 - secretion; Introns; Polymorphism, Single Nucleotide; Pregnancy; Promoter Regions, Genetic; Retrospective Studies; interleukin-10; haplotypes; idiopathic recurrent miscarriage

STUDY QUESTION Is recurrent pregnancy loss (RPL) associated with polymorphisms in the promoter and intron regions of the interleukin-10 (IL-10) gene? SUMMARY ANSWER IL-10 rs1518111 was found to be associated with RPL but the commonly studied promoter variants rs1800872, rs1800871 and 1800896 were no...