Fluticasone Reverses Oxymetazoline-induced Tachyphylaxis of Response and Rebound Congestion

• Published in: American journal of respiratory and critical care medicine Vol. 182; no. 1; pp. 19 - 24
• Main Authors: Vaidyanathan, Sriram, Williamson, Peter, Clearie, Karine, Khan, Faisel, Lipworth, Brian
• Format: Journal Article
• Language: English
• Published: New York, NY American Thoracic Society 01.07.2010
• Subjects: Administration, Intranasal; Administration, Oral; Adrenergic alpha-Agonists - administration & dosage; Adrenergic alpha-Agonists - adverse effects; Adrenergic alpha-Antagonists - administration & dosage; Adrenergic receptors; Adult; Airway management; Androstadienes - administration & dosage; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anti-Inflammatory Agents - administration & dosage; Biological and medical sciences; Clinical trials; Cold remedies; Cross-Over Studies; Double-Blind Method; Drug toxicity and drugs side effects treatment; Female; Fluticasone; Hay fever; Humans; Intensive care medicine; Male; Medical sciences; Middle Aged; Oxymetazoline - administration & dosage; Oxymetazoline - adverse effects; Pharmacology. Drug treatments; Prazosin - administration & dosage; Rhinitis; Steroids; Tachyphylaxis; Toxicity: blood; Young Adult; Corticosteroid; Agonist; Intensive care; Antiinflammatory agent; tachyphylaxis; α1-Adrenergic receptor; Oxymetazoline; Fluticasone; Antiasthma agent; up-regulation; adrenergic receptors; Nasal decongestant; Vasoconstrictor agent; α-Adrenergic receptor agonist; Rebound; Adrenergic receptor; Resuscitation

Chronic use of intranasal decongestants, such as oxymetazoline, leads to tachyphylaxis of response and rebound congestion, caused by alpha-adrenoceptor mediated down-regulation and desensitization of response. We evaluated if tachyphylaxis can be reversed by intranasal fluticasone propionate, and th...