Mendelian randomization analyses reveal novel drug targets for anorexia nervosa

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 112; p. 110427
• Main Authors: Yang, Jian, Fan, Yajuan, Yan, Bin, Zhao, Binbin, Qian, Li, Gao, Fengjie, Ma, Qingyan, Yang, Lihong, Wang, Wei, Bai, Ling, Zhu, Feng, Ma, Xiancang
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 10.01.2022
• Subjects: ADH1B; Alcohol Dehydrogenase - genetics; Anorexia nervosa; Anorexia Nervosa - drug therapy; Blood Proteins; Genome-Wide Association Study; Humans; Mendelian randomization; Mendelian Randomization Analysis; Pharmaceutical Preparations; Plasma proteome; Polymorphism, Single Nucleotide; Protein Disulfide Reductase (Glutathione) - genetics; Proteome; TXNDC12; Plasma proteome; TXNDC12; Anorexia nervosa; Mendelian randomization; ADH1B

Among all psychiatric disorders, anorexia nervosa (AN) has the highest mortality rate. However, there is still no pharmacological therapy for AN. The human plasma proteome may be a great cornerstone for the development of new drugs against AN. Here we performed a Mendelian randomization (MR) analysi...