Potentially Life-Threatening Interaction between Opioids and Intrathecal Baclofen in Individuals with a Childhood-Onset Neurological Disorder: A Case Series and Review of the Literature

• Published in: Neuropediatrics Vol. 55; no. 5; p. 294
• Main Authors: van Dijk, Liza M M, van Zwol, Annelies, Buizer, Annemieke I, van de Pol, Laura A, Slot, K Mariam, de Wildt, Saskia N, Bonouvrié, Laura A
• Format: Journal Article
• Language: English
• Published: Germany 01.10.2024
• Subjects: Adolescent; Analgesics, Opioid - administration & dosage; Analgesics, Opioid - adverse effects; Baclofen - administration & dosage; Baclofen - adverse effects; Child; Drug Interactions; Drug Overdose; Female; Humans; Injections, Spinal; Male; Muscle Relaxants, Central - administration & dosage; Muscle Relaxants, Central - adverse effects; Young Adult

Spasticity and dystonia are movement impairments that can occur in childhood-onset neurological disorders. Severely affected individuals can be treated with intrathecal baclofen (ITB). Concomitant use of ITB and opioids has been associated with central nervous system (CNS) depression. This study aim...