Signal transduction changes in CD4+ and CD8+ T cell subpopulations with aging

• Published in: Experimental gerontology Vol. 105; pp. 128 - 139
• Main Authors: Le Page, Aurélie, Dupuis, Gilles, Larbi, Anis, Witkowski, Jacek M., Fülöp, Tamas
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.05.2018
• Subjects: Adult; Aged; Aging - immunology; CD28 Antigens - immunology; CD4+ T cell subpopulations; CD4+ T cells; CD4-Positive T-Lymphocytes - immunology; CD8+ T cell subpopulations; CD8+ T cells; CD8-Positive T-Lymphocytes - immunology; Cell Differentiation; Female; Healthy Volunteers; Humans; Immunity, Innate; Lymphocyte Activation; Male; Signal Transduction; T cells; Young Adult; CD4+ T cell subpopulations; Signal transduction; CD8+ T cells; CD8+ T cell subpopulations; CD4+ T cells; T cells; CD8(+) T cells; CD8(+) T cell subpopulations; CD4(+) T cell subpopulations; CD4(+) T cells

The innate and adaptive branches of the immune system display changes with aging, a fact referred to as immunosenescence. Furthermore, it has been established that adaptive immunity is more susceptible to age-related changes than innate immunity. The most prominent phenotypic changes that reflect th...