Phosphorylation of connexin 43 induced by traumatic brain injury promotes exosome release

• Published in: Journal of neurophysiology Vol. 119; no. 1; pp. 305 - 311
• Main Authors: Chen, Wei, Guo, Yijun, Yang, Wenjin, Chen, Lei, Ren, Dabin, Wu, Chenxing, He, Bin, Zheng, Ping, Tong, Wusong
• Format: Journal Article
• Language: English
• Published: United States 01.01.2018
• Subjects: traumatic brain injury; exosome-based therapy; hippocampus; connexin 43; ERK

Traumatic brain injury (TBI) caused by the external force leads to the neuronal dysfunction and even death. TBI has been reported to significantly increase the phosphorylation of glial gap junction protein connexin 43 (Cx43), which in turn propagates damages into surrounding brain tissues. However,...