Night shift work and immune response to the meningococcal conjugate vaccine in healthy workers: a proof of concept study

• Published in: Sleep medicine Vol. 75; pp. 263 - 275
• Main Authors: Ruiz, Francieli S., Rosa, Daniela S., Zimberg, Ioná Z., dos Santos Quaresma, Marcus VL, Nunes, Jethe OF, Apostolico, Juliana S., Weckx, Lily Y., Souza, Alessandra R., Narciso, Fernanda V., Fernandes-Junior, Silvio A., Gonçalves, Bruno, Folkard, Simon, Bittencourt, Lia, Tufik, Sergio, Tulio de Mello, Marco
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2020
• Subjects: Cellular response; Cytokines; Human; Humoral response; Meningococcal C (MenC) vaccine; Sleep deprivation; Human; Humoral response; Cytokines; Meningococcal C (MenC) vaccine; Sleep deprivation; Cellular response

It is well-established that sleep regulates immune functions. Immunological functions are dependent on circadian rhythms and regular sleep as both have an impact on the magnitude of immune responses following antigenic challenge (eg, in vaccination). Here we investigated whether nocturnal shift work...