Antibiotic-induced mitochondrial dysfunction: Exploring tissue-specific effects on HEI-OC1 cells and peripheral blood mononuclear cells

• Published in: Biochimica et biophysica acta. General subjects Vol. 1869; no. 9; p. 130832
• Main Authors: Liu, Tianshi, Chamkha, Imen, Elmér, Eskil, Sjövall, Fredrik, Ehinger, Johannes K.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2025
• Subjects: Adenosine Triphosphate - metabolism; Anti-Bacterial Agents - adverse effects; Anti-Bacterial Agents - pharmacology; Antibiotics; ATP production; Cell Line; Cell Respiration - drug effects; Epithelial Cells - drug effects; Epithelial Cells - metabolism; HEI-OC1 cells; Humans; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - metabolism; Membrane Potential, Mitochondrial - drug effects; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial dysfunction; Organ Specificity; Ototoxicity; PBMCs; Reactive oxygen species; Reactive Oxygen Species - metabolism; Reactive oxygen species; Mitochondrial dysfunction; Antibiotics; ATP production; HEI-OC1 cells; PBMCs; Ototoxicity

Antibiotics are crucial in treating infectious diseases, particularly in intensive care unit patients, but they can lead to side effects such as ototoxicity. A mechanism for this is antibiotics targeting mitochondrial components in eucaryotic cells, due to their resemblance of those in bacteria. Her...