Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment

• Published in: Annals of neurology Vol. 51; no. 2; pp. 145 - 155
• Main Authors: DeKosky, Steven T., Ikonomovic, Milos D., Styren, Scot D., Beckett, Laurel, Wisniewski, Stephen, Bennett, David A., Cochran, Elizabeth J., Kordower, Jeffrey H., Mufson, Elliott J.
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01.02.2002
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Choline O-Acetyltransferase - metabolism; Cholinergic Fibers - enzymology; Cholinergic Fibers - pathology; Cognition Disorders - metabolism; Cognition Disorders - pathology; Female; Frontal Lobe - enzymology; Frontal Lobe - pathology; Hippocampus - enzymology; Hippocampus - pathology; Humans; Male; Neuropsychological Tests; Parietal Lobe - enzymology; Parietal Lobe - pathology; Temporal Lobe - enzymology; Temporal Lobe - pathology

In Alzheimer's disease (AD), loss of cortical and hippocampal choline acetyltransferase (ChAT) activity has been correlated with dementia severity and disease duration, and it forms the basis for current therapies. However, the extent to which reductions in ChAT activity are associated with ear...