Activity of sulfur-containing intermediate metabolites of spironolactone

• Published in: Clinical pharmacology and therapeutics Vol. 27; no. 3; p. 363
• Main Authors: McInnes, G T, Asbury, M J, Shelton, J R, Harrison, I R, Ramsay, L E, Venning, G R, Clarke, J M
• Format: Journal Article
• Language: English
• Published: United States 01.03.1980
• Subjects: Adult; Aldosterone; Diuresis - drug effects; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone - metabolism; Spironolactone - pharmacology; Structure-Activity Relationship

The renal antimineralocorticoid activity of single administration of 2 sulfur-containing compounds, which are thought to be intermediate metabolites of spironolactone, was assessed in healthy subjects. They were each active in reversing the urinary electrolyte changes indiced by fludrocortisone for...