The pan-Bcl-2 blocker obatoclax promotes the expression of Puma, Noxa, and Bim mRNA and induces apoptosis in neoplastic mast cells - Peter, Barbara; Cerny-Reiterer, Sabine; Hadzijusufovic, Emir; Schuch, Karina; Stefanzl, Gabriele; Eisenwort, Gregor; Gleixner, Karoline V; Hoermann, Gregor; Mayerhofer, Matthias; Kundi, Michael; Baumgartner, Sigrid; Sperr, Wolfgang R; et al. (Journal of leukocyte biology, 2014)
Keywords: Adult; Aged; Aged, 80 and over; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Apoptosis - drug effects; Apoptosis Regulatory Proteins - genetics; Bcl-2-Like Protein 11; bcl-X Protein - genetics; Cell Line, Tumor; Cell Proliferation - drug effects; Drug Resistance, Neoplasm - genetics; Drug Synergism; Female; Gene Expression Regulation, Neoplastic - drug effects; Humans; Male; Mast-Cell Sarcoma - drug therapy; Mast-Cell Sarcoma - genetics; Mast-Cell Sarcoma - mortality; mastocytosis; Mcl‐1; Membrane Proteins - genetics; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein - genetics; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins c-bcl-2 - genetics; Pyrroles - pharmacology; Pyrroles - therapeutic use; RNA, Messenger - genetics; targeted therapy; Mcl-1; targeted therapy; mastocytosis