Variations within Toll‐like receptor (TLR) and TLR signaling pathway‐related genes and their synergistic effects on the risk of Guillain‐Barré syndrome

• Published in: Journal of the peripheral nervous system Vol. 27; no. 2; pp. 131 - 143
• Main Authors: Dutta, Debprasad, Nagappa, Madhu, Sreekumaran Nair, Binu V., Das, Sumit Kumar, Wahatule, Rahul, Sinha, Sanjib, Vasanthapuram, Ravi, Taly, Arun B., Debnath, Monojit
• Format: Journal Article
• Language: English
• Published: Malden, USA Wiley Periodicals, Inc 01.06.2022; Wiley-Blackwell
• Subjects: Adaptor Proteins, Vesicular Transport - genetics; Adaptor Proteins, Vesicular Transport - pharmacology; Case-Control Studies; Genetic Predisposition to Disease - genetics; Genetics; Guillain-Barre Syndrome - genetics; Guillain‐Barré syndrome; Human genetics; Humans; Immunology; infection; inflammation; Innate immunity; Life Sciences; Myeloid Differentiation Factor 88 - genetics; Myeloid Differentiation Factor 88 - pharmacology; NF-KappaB Inhibitor alpha - genetics; Polymorphism, Single Nucleotide; Signal Transduction - genetics; single nucleotide polymorphism; TNF Receptor-Associated Factor 3 - genetics; TNF Receptor-Associated Factor 3 - pharmacology; TNF Receptor-Associated Factor 6 - genetics; TNF Receptor-Associated Factor 6 - pharmacology; Toll-Like Receptor 2 - genetics; Toll-Like Receptor 2 - metabolism; Toll-Like Receptor 3 - genetics; Toll-Like Receptor 4 - genetics; Toll-Like Receptor 4 - metabolism; Toll-Like Receptors - genetics; Toll‐like receptor; infection; inflammation; single nucleotide polymorphism; Guillain-Barré syndrome; Toll-like receptor

Guillain‐Barré syndrome (GBS) is the commonest post‐infectious polyradiculopathy. Although genetic background of the host seems to play an important role in the susceptibility to GBS, genes conferring major risk are not yet known. Dysregulation of Toll‐like receptor (TLR) molecules exacerbates immun...