A Possible Early Biomarker for Bicuspid Aortopathy: Circulating Transforming Growth Factor Beta-1 to Soluble Endoglin Ratio

• Published in: Circulation research Vol. 120; no. 11; pp. 1800 - 1811
• Main Authors: Forte, Amalia, Bancone, Ciro, Cobellis, Gilda, Buonocore, Marianna, Santarpino, Giuseppe, Fischlein, Theodor J.M., Cipollaro, Marilena, De Feo, Marisa, Della Corte, Alessandro
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 26.05.2017
• Subjects: Adult; Aged; Aortic Valve - abnormalities; Aortic Valve - diagnostic imaging; Aortic Valve - surgery; Aortic Valve Stenosis - blood; Aortic Valve Stenosis - diagnostic imaging; Aortic Valve Stenosis - surgery; Bicuspid Aortic Valve Disease; Biomarkers - blood; Echocardiography; Endoglin - blood; Female; Follow-Up Studies; Heart Valve Diseases - blood; Heart Valve Diseases - diagnostic imaging; Heart Valve Diseases - surgery; Humans; Male; Middle Aged; Transforming Growth Factor beta1 - blood; aortic valve stenosis; transforming growth factor-β1; endoglin; bicuspid; biomarkers; aortic disease

RATIONALE:The pathogenesis of bicuspid aortic valve (BAV)-associated aortopathy is poorly understood and no prognostic biomarker is currently available. OBJECTIVE:We aimed to identify putative circulating biomarkers pathogenetically and prognostically linked to bicuspid aortopathy. METHODS AND RESUL...