von Hippel-Lindau tumor suppressor protein represses platelet-derived growth factor B-chain gene expression via the Sp1 binding element in the proximal PDGF-B promoter

• Published in: Journal of cellular biochemistry Vol. 85; no. 3; pp. 490 - 495
• Main Authors: Rafty, Louise A., Khachigian, Levon M.
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 2002
• Subjects: Animals; Binding Sites; Cells, Cultured; Chloramphenicol O-Acetyltransferase - genetics; Chloramphenicol O-Acetyltransferase - metabolism; Down-Regulation; gene expression; Gene Expression Regulation - physiology; Ligases - genetics; Ligases - metabolism; Muscle, Smooth, Vascular - cytology; Muscle, Smooth, Vascular - physiology; platelet-derived growth factor B-chain; Promoter Regions, Genetic; Proto-Oncogene Proteins c-sis - genetics; Proto-Oncogene Proteins c-sis - metabolism; Rats; Rats, Inbred WKY; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Repressor Proteins - genetics; Repressor Proteins - metabolism; Sp1 Transcription Factor - metabolism; transcription; Transcription, Genetic; Transfection; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; von Hippel-Lindau protein; Von Hippel-Lindau Tumor Suppressor Protein

VHL is the causative gene for von Hippel‐Lindau disease and sporadic clear cell renal cancer. It has been shown that pVHL can suppress the expression of certain genes that are overexpressed in renal carcinomas. One such gene is that encoding the potent mitogen and chemoattractant, platelet‐derived g...