Validation of deep learning-based nonspecific estimates for amyloid burden quantification with longitudinal data

• Published in: Physica medica Vol. 99; pp. 85 - 93
• Main Authors: Nai, Ying-Hwey, Liu, Haohui, Reilhac, Anthonin
• Format: Journal Article
• Language: English
• Published: Italy Elsevier Ltd 01.07.2022
• Subjects: Alzheimer’s disease; Amyloid-Beta Positron Emission Tomography (Aβ-PET); Deep learning; Nonspecific uptake; Deep learning; Nonspecific uptake; Alzheimer’s disease; Amyloid-Beta Positron Emission Tomography (Aβ-PET)

[Display omitted] •New Amyloid PET biomarker correlated better than SUVr with cognitive decline.•New Amyloid biomarker validated with fluorinated radiotracer and longitudinal data.•Nonspecific uptake can be estimated from structural MR images using deep learning.•Multimodal network with T1- and T2-w...