Contrast Enhancement of Cochlea after Direct Microneedle Intracochlear Injection of Gadodiamide through the Round Window Membrane with Minimal Dosage

• Published in: Academic radiology Vol. 32; no. 4; p. 2152
• Main Authors: Zhou, Chaoqun, Feng, Sharon J, Leong, Stephen, Breil, Eugénie, Voruz, François, Valentini, Chris, Hammer, Daniella R, Aksit, Aykut, Olson, Elizabeth S, Guo, Jia, Kysar, Jeffrey W, Lalwani, Anil K
• Format: Journal Article
• Language: English
• Published: United States 01.04.2025
• Subjects: Animals; Cochlea - pathology; Contrast Media - administration & dosage; Endolymphatic Hydrops; Gadolinium DTPA - administration & dosage; Guinea Pigs; Magnetic Resonance Imaging - methods; Microinjections - instrumentation; Microinjections - methods; Needles; Round Window, Ear; Round window membrane; Contrast-enhanced magnetic resonance imaging; Intracochlear delivery; Microneedle; Endolymphatic hydrops

The potential of contrast-enhanced MRI for diagnosing endolymphatic hydrops is limited by long wait times following intravenous (IV) or intratympanic (IT) delivery, high contrast dosages, and inconsistent signal intensity enhancements. This study investigates microneedle-mediated intracochlear (IC)...