Desmoglein 2 can undergo Ca2+-dependent interactions with both desmosomal and classical cadherins including E-cadherin and N-cadherin

• Published in: Biophysical journal Vol. 121; no. 7; pp. 1322 - 1335
• Main Authors: Fuchs, Michael, Kugelmann, Daniela, Schlegel, Nicolas, Vielmuth, Franziska, Waschke, Jens
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 05.04.2022; The Biophysical Society

Desmoglein (Dsg) 2 is a ubiquitously expressed desmosomal cadherin. Particularly, it is present in all cell types forming desmosomes, including epithelial cells and cardiac myocytes and is upregulated in the autoimmune skin disease pemphigus. Thus, we here characterized the binding properties of Dsg...