Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis

• Published in: Development (Cambridge) Vol. 129; no. 8; pp. 2015 - 2030
• Main Authors: Kalev-Zylinska, Maggie L., Horsfield, Julia A., Flores, Maria Vega C., Postlethwait, John H., Vitas, Maria R., Baas, Andrea M., Crosier, Philip S., Crosier, Kathryn E.
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Limited 15.04.2002
• Subjects: Acute Disease; Amino Acid Sequence; Animals; Base Sequence; Cell Differentiation; Core Binding Factor Alpha 2 Subunit; Disease Models, Animal; DNA, Complementary; DNA-Binding Proteins - classification; DNA-Binding Proteins - genetics; DNA-Binding Proteins - physiology; Gene Expression; Hematopoiesis - physiology; Hematopoietic Stem Cells - metabolism; Humans; Leukemia, Myeloid - genetics; Leukemia, Myeloid - metabolism; Leukemia, Myeloid - physiopathology; Mice; Microinjections; Molecular Sequence Data; Neovascularization, Pathologic; Neurons - metabolism; Neurons - physiology; Oncogene Proteins, Fusion - genetics; Oncogene Proteins, Fusion - physiology; Proto-Oncogene Proteins; RUNX1 Translocation Partner 1 Protein; T-Box Domain Proteins - genetics; Transcription Factors - classification; Transcription Factors - genetics; Transcription Factors - physiology; Transgenes; Zebrafish - embryology; Zebrafish - genetics; Zebrafish - metabolism; Zebrafish Proteins - genetics

RUNX1/AML1/CBFA2 is essential for definitive hematopoiesis, and chromosomal translocations affecting RUNX1 are frequently involved in human leukemias. Consequently, the normal function of RUNX1 and its involvement in leukemogenesis remain subject to intensive research. To further elucidate the role...