Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis - Kalev-Zylinska, Maggie L.; Horsfield, Julia A.; Flores, Maria Vega C.; Postlethwait, John H.; Vitas, Maria R.; Baas, Andrea M.; Crosier, Philip S.; Crosier, Kathryn E. (Development (Cambridge), 2002)
Keywords: Acute Disease; Amino Acid Sequence; Animals; Base Sequence; Cell Differentiation; Core Binding Factor Alpha 2 Subunit; Disease Models, Animal; DNA, Complementary; DNA-Binding Proteins - classification; DNA-Binding Proteins - genetics; DNA-Binding Proteins - physiology; Gene Expression; Hematopoiesis - physiology; Hematopoietic Stem Cells - metabolism; Humans; Leukemia, Myeloid - genetics; Leukemia, Myeloid - metabolism; Leukemia, Myeloid - physiopathology; Mice; Microinjections; Molecular Sequence Data; Neovascularization, Pathologic; Neurons - metabolism; Neurons - physiology; Oncogene Proteins, Fusion - genetics; Oncogene Proteins, Fusion - physiology; Proto-Oncogene Proteins; RUNX1 Translocation Partner 1 Protein; T-Box Domain Proteins - genetics; Transcription Factors - classification; Transcription Factors - genetics; Transcription Factors - physiology; Transgenes; Zebrafish - embryology; Zebrafish - genetics; Zebrafish - metabolism; Zebrafish Proteins - genetics