No relationship exists between itai-itai disease and TA repeat polymorphisms of the estrogen receptor α gene

Itai-itai (ouch-ouch) disease is a syndrome accompanied by bone mineral disorders that may be related to oral cadmium exposure. Itai-itai predominantly affects postmenopausal women with a history of multiple childbirth. In a previous study we have examined the genotype distributions of PvuII and Xba...

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Published inArchives of toxicology Vol. 76; no. 8; pp. 467 - 469
Main Authors AHMAD HAMIM SADEWA, MIYABE, Yuri, NISHIO, Hisahide, HAYASHI, Chiyo, SUTOMO, Retno, MYEONG JIN LEE, AYAKI, Hitoshi, KOIZUMI, Naoko, SUMINO, Kimiaki
Format Journal Article
LanguageEnglish
Published Berlin Springer 01.08.2002
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Abstract Itai-itai (ouch-ouch) disease is a syndrome accompanied by bone mineral disorders that may be related to oral cadmium exposure. Itai-itai predominantly affects postmenopausal women with a history of multiple childbirth. In a previous study we have examined the genotype distributions of PvuII and XbaI restriction fragment length polymorphisms of the estrogen receptor alpha (ER alpha) gene in patients with itai-itai disease and compared them with those of controls. However, no significant differences were shown between the genotype distributions of the patients and controls. In the present study, we determined the TA repeat polymorphisms of the patients and controls. The distributions of the patients were: HH 25.0%, HL 50.0%, and LL 25.0%; where HH includes two alleles with a high number of TA repeats (TA> or =16), HL includes one high number allele and one low number allele (TA< or =15), and LL includes two alleles with a low number of TA repeats. These patients' distributions were not significantly different from those of the controls. Although our sample number was limited, we concluded that a polymorphism variant of the ER alpha gene is not a predisposing factor for itai-itai disease.
AbstractList Itai-itai (ouch-ouch) disease is a syndrome accompanied by bone mineral disorders that may be related to oral cadmium exposure. Itai-itai predominantly affects postmenopausal women with a history of multiple childbirth. In a previous study we have examined the genotype distributions of PvuII and XbaI restriction fragment length polymorphisms of the estrogen receptor alpha (ER alpha ) gene in patients with itai-itai disease and compared them with those of controls. However, no significant differences were shown between the genotype distributions of the patients and controls. In the present study, we determined the TA repeat polymorphisms of the patients and controls. The distributions of the patients were: HH 25.0%, HL 50.0%, and LL 25.0%; where HH includes two alleles with a high number of TA repeats (TA16), HL includes one high number allele and one low number allele (TA less than or equal to 15), and LL includes two alleles with a low number of TA repeats. These patients' distributions were not significantly different from those of the controls. Although our sample number was limited, we concluded that a polymorphism variant of the ER alpha gene is not a predisposing factor for itai-itai disease.
Itai-itai (ouch-ouch) disease is a syndrome accompanied by bone mineral disorders that may be related to oral cadmium exposure. Itai-itai predominantly affects postmenopausal women with a history of multiple childbirth. In a previous study we have examined the genotype distributions of PvuII and XbaI restriction fragment length polymorphisms of the estrogen receptor alpha (ER alpha) gene in patients with itai-itai disease and compared them with those of controls. However, no significant differences were shown between the genotype distributions of the patients and controls. In the present study, we determined the TA repeat polymorphisms of the patients and controls. The distributions of the patients were: HH 25.0%, HL 50.0%, and LL 25.0%; where HH includes two alleles with a high number of TA repeats (TA> or =16), HL includes one high number allele and one low number allele (TA< or =15), and LL includes two alleles with a low number of TA repeats. These patients' distributions were not significantly different from those of the controls. Although our sample number was limited, we concluded that a polymorphism variant of the ER alpha gene is not a predisposing factor for itai-itai disease.
Author SUTOMO, Retno
MIYABE, Yuri
AHMAD HAMIM SADEWA
MYEONG JIN LEE
SUMINO, Kimiaki
AYAKI, Hitoshi
KOIZUMI, Naoko
NISHIO, Hisahide
HAYASHI, Chiyo
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Keywords Human
Estrogen receptor α
Itai Itai disease
Repeated sequence
Genetics
Nucleoside
Polymorphism
Language English
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Snippet Itai-itai (ouch-ouch) disease is a syndrome accompanied by bone mineral disorders that may be related to oral cadmium exposure. Itai-itai predominantly affects...
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StartPage 467
SubjectTerms Biological and medical sciences
Cadmium Poisoning - genetics
Diseases of the osteoarticular system
Environmental Exposure
Estrogen Receptor alpha
Female
Gene Frequency - genetics
Genotype
Humans
Japan
Medical sciences
Osteoporosis. Osteomalacia. Paget disease
Polymorphism, Genetic - genetics
Polymorphism, Restriction Fragment Length
Receptors, Estrogen - genetics
Tandem Repeat Sequences - genetics
Title No relationship exists between itai-itai disease and TA repeat polymorphisms of the estrogen receptor α gene
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