Effects of Fosinopril and Pravastatin on Cardiovascular Events in Subjects With Microalbuminuria

• Published in: Circulation (New York, N.Y.) Vol. 110; no. 18; pp. 2809 - 2816
• Main Authors: Asselbergs, Folkert W., Diercks, Gilles F.H., Hillege, Hans L., van Boven, Ad J., Janssen, Wilbert M.T., Voors, Adriaan A., de Zeeuw, Dick, de Jong, Paul E., van Veldhuisen, Dirk J., van Gilst, Wiek H.
• Format: Journal Article
• Language: English
• Published: United States 02.11.2004
• Subjects: Adult; Aged; Albuminuria - complications; Albuminuria - drug therapy; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - mortality; Cardiovascular Diseases - prevention & control; Cohort Studies; Double-Blind Method; Female; Follow-Up Studies; Fosinopril - pharmacology; Fosinopril - therapeutic use; Hospitalization - statistics & numerical data; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Incidence; Life Tables; Male; Middle Aged; Pravastatin - pharmacology; Pravastatin - therapeutic use; Treatment Outcome

Background— Microalbuminuria is associated with increased risk of cardiovascular events. We assessed whether therapeutic intervention aimed at lowering urinary albumin excretion would reduce cardiovascular events in microalbuminuric subjects (15 to 300 mg/24 hours). Methods and Results— From the Pre...