Rapid and sensitive determination of aprindine in serum by gas chromatography using a surface ionization detector

A rapid and highly sensitive method for the determination in serum of aprindine, an antiarrhythmic drug, was developed employing gas chromatography with a surface ionization detector. No interfering peak from endogenous substances appeared when an organic phase was directly injected into the system...

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Bibliographic Details
Published inJournal of chromatography Vol. 493; no. 1; pp. 71 - 78
Main Authors Kawano, Hitomi, Inotsume, Nobuo, Arimoto, Hiromi, Fujii, Toshihiro, Nakano, Masahiro
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 1989
Elsevier
Subjects
Adolescent
Analytical biochemistry: general aspects, technics, instrumentation
Analytical, structural and metabolic biochemistry
Aprindine - blood
Aprindine - metabolism
Aprindine - pharmacokinetics
Biological and medical sciences
Chromatography, Gas
Female
Flame Ionization
Fundamental and applied biological sciences. Psychology
Humans
Imipramine - blood
Indenes - blood
Human
Gas chromatography
Detector
Clinical biology
Surface ionization
Serum
Chromatogram
Pharmacokinetics
Retention time
Antiarrhythmia agent
Blood
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Summary:A rapid and highly sensitive method for the determination in serum of aprindine, an antiarrhythmic drug, was developed employing gas chromatography with a surface ionization detector. No interfering peak from endogenous substances appeared when an organic phase was directly injected into the system after single extraction from a serum sample. A standard curve obtained was linear up to the serum level of 6 μg/ml, and the limit of sensitivity was 16 pg. The method described is applicable to routine therapeutic monitoring of serum concentrations of aprindine.
ISSN:0378-4347
DOI:10.1016/S0378-4347(00)82710-3