Latent-TGF-beta: an overview
The latency associated with the transforming growth factor-betas (TGF-betas) was discovered in 1984. Since the two publications on this subject in that year, there has been on average over sixty reports in which latency was the dominant theme for each of the past 10 years, proof enough of the intere...
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| Published in | Molecular and cellular biochemistry Vol. 219; no. 1-2; pp. 163 - 170 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Springer Verlag
01.03.2001
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The latency associated with the transforming growth factor-betas (TGF-betas) was discovered in 1984. Since the two publications on this subject in that year, there has been on average over sixty reports in which latency was the dominant theme for each of the past 10 years, proof enough of the interest in this field of growth factor research. As the mature 25 kD forms of the TGF-betas are required for them to exert their many, diverse biological effects, it was inevitable that an explanation of the structure and of the activation of the latent complexes be sought. This overview provides a description of these essential points. Now that it has been clearly shown that dysregulation of particular components of the TGF-beta signalling pathway is implicated in many human diseases, the activation of the latent TGF-beta complexes has taken on added importance. Technical improvements enable the distinction of active and latent TGF-beta proteins in vivo and have started to reveal anomalies in the control of activation in relation to various pathological situations. |
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| AbstractList | The latency associated with the transforming growth factor-betas (TGF-betas) was discovered in 1984. Since the two publications on this subject in that year, there has been on average over sixty reports in which latency was the dominant theme for each of the past 10 years, proof enough of the interest in this field of growth factor research. As the mature 25 kD forms of the TGF-betas are required for them to exert their many, diverse biological effects, it was inevitable that an explanation of the structure and of the activation of the latent complexes be sought. This overview provides a description of these essential points. Now that it has been clearly shown that dysregulation of particular components of the TGF-beta signalling pathway is implicated in many human diseases, the activation of the latent TGF-beta complexes has taken on added importance. Technical improvements enable the distinction of active and latent TGF-beta proteins in vivo and have started to reveal anomalies in the control of activation in relation to various pathological situations.The latency associated with the transforming growth factor-betas (TGF-betas) was discovered in 1984. Since the two publications on this subject in that year, there has been on average over sixty reports in which latency was the dominant theme for each of the past 10 years, proof enough of the interest in this field of growth factor research. As the mature 25 kD forms of the TGF-betas are required for them to exert their many, diverse biological effects, it was inevitable that an explanation of the structure and of the activation of the latent complexes be sought. This overview provides a description of these essential points. Now that it has been clearly shown that dysregulation of particular components of the TGF-beta signalling pathway is implicated in many human diseases, the activation of the latent TGF-beta complexes has taken on added importance. Technical improvements enable the distinction of active and latent TGF-beta proteins in vivo and have started to reveal anomalies in the control of activation in relation to various pathological situations. The latency associated with the transforming growth factor-betas (TGF-betas) was discovered in 1984. Since the two publications on this subject in that year, there has been on average over sixty reports in which latency was the dominant theme for each of the past 10 years, proof enough of the interest in this field of growth factor research. As the mature 25 kD forms of the TGF-betas are required for them to exert their many, diverse biological effects, it was inevitable that an explanation of the structure and of the activation of the latent complexes be sought. This overview provides a description of these essential points. Now that it has been clearly shown that dysregulation of particular components of the TGF-beta signalling pathway is implicated in many human diseases, the activation of the latent TGF-beta complexes has taken on added importance. Technical improvements enable the distinction of active and latent TGF-beta proteins in vivo and have started to reveal anomalies in the control of activation in relation to various pathological situations. |
| Author | Lawrence, David A. |
| Author_xml | – sequence: 1 givenname: David A. surname: Lawrence fullname: Lawrence, David A. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11354248$$D View this record in MEDLINE/PubMed https://hal.inrae.fr/hal-02677294$$DView record in HAL |
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| Keywords | TGF-BETA |
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| Snippet | The latency associated with the transforming growth factor-betas (TGF-betas) was discovered in 1984. Since the two publications on this subject in that year,... |
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| SubjectTerms | Animals Biotransformation - immunology Biotransformation - physiology Carrier Proteins - chemistry Carrier Proteins - classification Carrier Proteins - genetics Carrier Proteins - metabolism Fibrosis - etiology Fibrosis - pathology Humans Hydrogen-Ion Concentration Intracellular Signaling Peptides and Proteins Latent TGF-beta Binding Proteins Life Sciences Neoplasms - etiology Neoplasms - pathology Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - metabolism Radiation, Ionizing Solubility transforming growth factors |
| Title | Latent-TGF-beta: an overview |
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