Diet-induced changes in glucose and triglycerides are associated with changes in plasminogen activator inhibitor levels

Twenty-four healthy female subjects volunteered to participate in an experiment in which they maintained a high-fat/low-carbohydrate (CHO) diet followed by a low-fat/high-CHO diet or vice versa in a cross-over study design. In bivariate correlation analysis, only glucose (r = 0.52, p less than 0.05)...

Full description

Saved in:
Bibliographic Details
Published inHaemostasis Vol. 21; no. 3; p. 175
Main Authors Sundell, I B, Dahlén, G H, Rånby, M
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1991
Subjects
Adult
Blood Glucose - metabolism
Dietary Carbohydrates - pharmacology
Dietary Fats - pharmacology
Female
Humans
Hydrocortisone - urine
Insulin - blood
Lipids - blood
Lipoprotein(a)
Lipoproteins - blood
Plasminogen - metabolism
Plasminogen Inactivators - blood
Tissue Plasminogen Activator - immunology
Online AccessGet more information

Cover

More Information
Summary:Twenty-four healthy female subjects volunteered to participate in an experiment in which they maintained a high-fat/low-carbohydrate (CHO) diet followed by a low-fat/high-CHO diet or vice versa in a cross-over study design. In bivariate correlation analysis, only glucose (r = 0.52, p less than 0.05) and triglycerides (r = 0.53, p less than 0.05) correlated with changes in plasminogen activator inhibitor type 1 (PAI-1) activity. A second-degree polynomial response surface model suggested that transition from a high-fat/low-CHO diet to a low-fat/high-CHO diet is associated with reduced levels of PAI-1 provided that glucose and triglyceride levels are not elevated by more than 1.2 and 0.5 mmol/l, respectively.
ISSN:0301-0147
DOI:10.1159/000216223