Simultaneous Determination and Pharmacokinetic Study of Metformin and Rosiglitazone in Human Plasma by HPLC-ESI-MS - Chen, Lingyun; Zhou, Zhifeng; Shen, Mei; Ma, Ande (Journal of chromatographic science, 2011)
Keywords: Analysis; Biological and medical sciences; Chromatography, High Pressure Liquid - methods; Drug Stability; Female; General pharmacology; Humans; Least-Squares Analysis; Male; Medical sciences; Metformin - blood; Metformin - chemistry; Metformin - pharmacokinetics; Pharmacology. Drug treatments; Phenformin - analysis; Reproducibility of Results; Rosiglitazone; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization - methods; Thiazolidinediones - blood; Thiazolidinediones - chemistry; Thiazolidinediones - pharmacokinetics; Human; Validation; Biological fluid; Tandem mass spectrometry; Chemical analysis; Healthy subject; Coupled method; Oral administration; HPLC chromatography; Thiazolidinedione derivatives; Electrospray; Blood; Blood plasma; Hypoglycemic agent; Biguanides; Simultaneous measurement; Rosiglitazone; Metformin; Pharmacokinetics; Quantitative analysis