Visualizing in situ viral replication across the natural history of chronic HBV infection

• Published in: Hepatology communications Vol. 7; no. 4
• Main Authors: Zhang, Hanyue, Zhang, Miaoqu, Zhang, Qiran, Yu, Yiqi, Zhang, Fan, Wang, Jing, Zhou, Mingzhe, Yu, Tong, Shen, Chuan, Yu, Shuili, Huang, Yanfang, Huang, Yuxian, Zhang, Jiming, Jin, Jie, Qiu, Chao, Guojun, Li, Zhang, Wenhong
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 01.04.2023
• Subjects: DNA, Circular - genetics; DNA, Viral - genetics; Hepatitis B virus; Hepatitis B, Chronic; Humans; Original; Virus Replication - genetics

Chronic HBV infection evolves through different phases. Interactions between viral replication and the host immune response in the liver underlie the pathogenesis of this disease. The aim of this study was to directly visualize the HBV replication intermediates at a single-cell resolution inscribed...