Thymic microchimerism correlates with the outcome of tolerance-inducing protocols for solid organ transplantation

• Published in: Journal of the American Society of Nephrology Vol. 12; no. 12; pp. 2815 - 2826
• Main Authors: NORIS, Marina, CUGINI, Daniela, REMUZZI, Giuseppe, CASIRAGHI, Federica, AZZOLLINI, Nadia, DE DEUS VIERA MORAES, Luciana, MISTER, Marilena, PEZZOTTA, Angela, CAVINATO, Regiane Aparecida, AIELLO, Sistiana, PERICO, Norberto
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.12.2001
• Subjects: Animals; Biological and medical sciences; Bone Marrow Cells - immunology; Bone Marrow Transplantation; Graft Survival; Histocompatibility Antigens Class II - analysis; Kidney Transplantation; Lymphocyte Culture Test, Mixed; Lymphocyte Transfusion; Male; Medical sciences; Monocytes - immunology; Monocytes - transplantation; Rats; Rats, Inbred BN; Rats, Inbred Lew; Rats, Inbred WF; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the urinary system; Thymectomy; Thymus Gland - physiology; Tissue Donors; Transplantation Chimera; Transplantation Conditioning; Transplantation Tolerance; Transplantation, Homologous; Treatment Outcome; Kidney disease; Human; Urinary system disease; Prognosis; Thymus gland; Exploration; Transplantation; Cellular immunity; Homotransplantation; Kidney; Treatment; Surgery; Renal failure; T-Lymphocyte

This study found that pretransplant infusion of donor peripheral blood leukocytes, either total leukocytes (peripheral blood leukocytes) or peripheral blood mononuclear cells (PBMC), under appropriate immunomodulating conditions was more effective than donor bone marrow (BM) in prolonging the surviv...