NK1 receptor blockade disrupts microtumor growth and aggregation in a three-dimensional murine breast cancer model

• Published in: Neuropeptides (Edinburgh) Vol. 109; p. 102479
• Main Authors: Gutierrez, Silvia, Boada, M. Danilo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.01.2025
• Subjects: Aprepitant; Breast cancer; Microtumors; Neuropeptides; NK1R; Substance P; Aprepitant; Neuropeptides; NK1R; Breast cancer; Substance P; Microtumors

Several data indicate that Substance P (SP) neurokinin type 1 receptor (NK1R) is at the center of the interaction between cancer cells and peripheral sensory neurons. Selecting the appropriate cancer cell line and its susceptibility to being modulated by NK1 antagonists are critical to studying this...