Subcutaneous injection of desmopressin (DDAVP): evaluation of a new, more concentrated preparation

• Published in: Haemostasis Vol. 19; no. 1; p. 38
• Main Authors: Köhler, M, Hellstern, P, Tarrach, H, Bambauer, R, Wenzel, E, Jutzler, G A
• Format: Journal Article
• Language: English
• Published: Switzerland 1989
• Subjects: Adult; Antigens - analysis; Bleeding Time; Blood Coagulation Disorders - drug therapy; Blood Coagulation Disorders - etiology; Deamino Arginine Vasopressin - administration & dosage; Drug Evaluation; Factor VIII - analysis; Female; Hemophilia A - drug therapy; Heterozygote; Humans; Injections, Subcutaneous; Male; Middle Aged; Uremia - complications; von Willebrand Factor - analysis

A more concentrated desmopressin (DDAVP) preparation (40 micrograms/ml), which required small injection volumes (less than 1 ml), was studied in a double-blind trial in 10 healthy volunteers, 12 patients with haemophilia A, and 8 patients with uraemic bleeding. DDAVP was administered by subcutaneous...