Immunologic profile of highly exposed yet HIV type 1-seronegative men

• Published in: AIDS research and human retroviruses Vol. 18; no. 14; p. 1051
• Main Authors: Yang, Otto O, Boscardin, W John, Matud, Jose, Hausner, Mary Ann, Hultin, Lance E, Hultin, Patricia M, Shih, Roger, Ferbas, John, Siegal, Frederick P, Shodell, Michael, Shearer, Gene M, Grene, Edith, Carrington, Mary, O'Brien, Steve, Price, Charles B, Detels, Roger, Jamieson, Beth D, Giorgi, Janis V
• Format: Journal Article
• Language: English
• Published: United States 20.09.2002
• Subjects: Adult; Amino Acid Sequence; Chronic Disease; Cytokines - biosynthesis; HIV Seronegativity - immunology; HIV-1 - immunology; Humans; Immunity, Cellular; Immunophenotyping; Interferon-gamma - biosynthesis; Male; Peptides - chemical synthesis; Peptides - chemistry; Peptides - immunology; Receptors, CCR5 - metabolism; Retroviridae Proteins - chemistry; T-Lymphocytes, Cytotoxic - immunology; T-Lymphocytes, Helper-Inducer - immunology; Virus Diseases - immunology

The host immune factors that determine susceptibility to HIV-1 infection are poorly understood. We compared multiple immunologic parameters in three groups of HIV-1-seronegative men: 14 highly exposed (HR10), 7 previously reported possibly to have sustained transient infection (PTI), and a control g...