Synthesis, molecular properties and DFT studies of new phosphoramidates as potential urease inhibitors

• Published in: Medicinal chemistry research Vol. 23; no. 12; pp. 5174 - 5187
• Main Authors: Oliveira, Fabricio M., Barbosa, Luiz C. A., Demuner, Antônio J., Maltha, Célia R. A., Pereira, Silvana R., Horta, Lívia P., Modolo, Luzia V.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2014
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Original Research; Pharmacology/Toxicology; Urease inhibitors; Phosphoramidates; Canavalia ensiformis; DFT Studies; Jack bean urease

In this work, new phosphoramidates were prepared and screened for their putative urease inhibitory activity. The importance of this class of compounds is related to the wide range of biological activities which they exhibit. Consequently, higher activity shown by phosphoramidates 3a , 4b , 5a , 5b ,...