Alterations of plasma magnesium, copper, zinc, iron and selenium concentrations and some related erythrocyte antioxidant enzyme activities in patients with Alzheimer’s disease
The aim of the present study is to evaluate the status of plasma essential trace elements magnesium (Mg), copper (Cu), zinc (Zn), iron (Fe) and selenium (Se) concentrations and their some related antioxidant enzyme activities, erythrocyte glutathione peroxidase (GPx), superoxide dismutase (SOD), and...
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| Published in | Journal of trace elements in medicine and biology Vol. 24; no. 3; pp. 169 - 173 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Germany
Elsevier GmbH
01.07.2010
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0946-672X 1878-3252 1878-3252 |
| DOI | 10.1016/j.jtemb.2010.02.002 |
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| Abstract | The aim of the present study is to evaluate the status of plasma essential trace elements magnesium (Mg), copper (Cu), zinc (Zn), iron (Fe) and selenium (Se) concentrations and their some related antioxidant enzyme activities, erythrocyte glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) activities in patients with Alzheimer’s disease (AD). Fifty patients with AD and fifty healthy control subjects were included in this study. Plasma Cu and Zn concentrations by atomic absorption spectrometry (AAS), plasma Mg and Fe concentrations by spectrophotometric methods and plasma Se concentrations by graphite furnace AAS were determined. Erythrocyte GPx, SOD and CAT activities were measured by spectrophotometric methods. Plasma Mg, Cu, Zn, Fe and Se levels and erythrocyte GPx, SOD and CAT activities were found to be significantly lower in patients with AD compared with controls. These results suggest that alterations in essential trace elements and their related enzymes may play a role in the etiopathogenesis of AD. Also, there is a defect in the antioxidant defense system, which may lead to oxidative damage in patients with AD. The changes in antioxidant enzyme activities may be secondary to the alterations in their cofactor concentrations. |
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| AbstractList | The aim of the present study is to evaluate the status of plasma essential trace elements magnesium (Mg), copper (Cu), zinc (Zn), iron (Fe) and selenium (Se) concentrations and their some related antioxidant enzyme activities, erythrocyte glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) activities in patients with Alzheimer's disease (AD). Fifty patients with AD and fifty healthy control subjects were included in this study. Plasma Cu and Zn concentrations by atomic absorption spectrometry (AAS), plasma Mg and Fe concentrations by spectrophotometric methods and plasma Se concentrations by graphite furnace AAS were determined. Erythrocyte GPx, SOD and CAT activities were measured by spectrophotometric methods. Plasma Mg, Cu, Zn, Fe and Se levels and erythrocyte GPx, SOD and CAT activities were found to be significantly lower in patients with AD compared with controls. These results suggest that alterations in essential trace elements and their related enzymes may play a role in the etiopathogenesis of AD. Also, there is a defect in the antioxidant defense system, which may lead to oxidative damage in patients with AD. The changes in antioxidant enzyme activities may be secondary to the alterations in their cofactor concentrations.The aim of the present study is to evaluate the status of plasma essential trace elements magnesium (Mg), copper (Cu), zinc (Zn), iron (Fe) and selenium (Se) concentrations and their some related antioxidant enzyme activities, erythrocyte glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) activities in patients with Alzheimer's disease (AD). Fifty patients with AD and fifty healthy control subjects were included in this study. Plasma Cu and Zn concentrations by atomic absorption spectrometry (AAS), plasma Mg and Fe concentrations by spectrophotometric methods and plasma Se concentrations by graphite furnace AAS were determined. Erythrocyte GPx, SOD and CAT activities were measured by spectrophotometric methods. Plasma Mg, Cu, Zn, Fe and Se levels and erythrocyte GPx, SOD and CAT activities were found to be significantly lower in patients with AD compared with controls. These results suggest that alterations in essential trace elements and their related enzymes may play a role in the etiopathogenesis of AD. Also, there is a defect in the antioxidant defense system, which may lead to oxidative damage in patients with AD. The changes in antioxidant enzyme activities may be secondary to the alterations in their cofactor concentrations. The aim of the present study is to evaluate the status of plasma essential trace elements magnesium (Mg), copper (Cu), zinc (Zn), iron (Fe) and selenium (Se) concentrations and their some related antioxidant enzyme activities, erythrocyte glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) activities in patients with Alzheimer's disease (AD). Fifty patients with AD and fifty healthy control subjects were included in this study. Plasma Cu and Zn concentrations by atomic absorption spectrometry (AAS), plasma Mg and Fe concentrations by spectrophotometric methods and plasma Se concentrations by graphite furnace AAS were determined. Erythrocyte GPx, SOD and CAT activities were measured by spectrophotometric methods. Plasma Mg, Cu, Zn, Fe and Se levels and erythrocyte GPx, SOD and CAT activities were found to be significantly lower in patients with AD compared with controls. These results suggest that alterations in essential trace elements and their related enzymes may play a role in the etiopathogenesis of AD. Also, there is a defect in the antioxidant defense system, which may lead to oxidative damage in patients with AD. The changes in antioxidant enzyme activities may be secondary to the alterations in their cofactor concentrations. |
| Author | Delibas, Namik Demirin, Hilmi Vural, Huseyin Kara, Yusuf Eren, Ibrahim |
| Author_xml | – sequence: 1 givenname: Huseyin surname: Vural fullname: Vural, Huseyin email: vuralh@yahoo.com organization: Department of Biochemistry, Suleyman Demirel University, Faculty of Medicine, 32260, Isparta, Turkey – sequence: 2 givenname: Hilmi surname: Demirin fullname: Demirin, Hilmi organization: Department of Biochemistry, Suleyman Demirel University, Faculty of Medicine, 32260, Isparta, Turkey – sequence: 3 givenname: Yusuf surname: Kara fullname: Kara, Yusuf organization: Department of Biochemistry, Suleyman Demirel University, Faculty of Medicine, 32260, Isparta, Turkey – sequence: 4 givenname: Ibrahim surname: Eren fullname: Eren, Ibrahim organization: Department of Psychiatry, Suleyman Demirel University, Faculty of Medicine, Isparta, Turkey – sequence: 5 givenname: Namik surname: Delibas fullname: Delibas, Namik organization: Department of Biochemistry, Suleyman Demirel University, Faculty of Medicine, 32260, Isparta, Turkey |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20569929$$D View this record in MEDLINE/PubMed |
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| Keywords | Alzheimer’s disease Antioxidant enzymes Trace elements |
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| Snippet | The aim of the present study is to evaluate the status of plasma essential trace elements magnesium (Mg), copper (Cu), zinc (Zn), iron (Fe) and selenium (Se)... |
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| SubjectTerms | Aged Alzheimer Disease - blood Alzheimer Disease - enzymology Alzheimer’s disease Antioxidant enzymes Antioxidants - metabolism Catalase - blood Copper - blood Erythrocytes - enzymology Female Glutathione Peroxidase - blood Humans Iron - blood Magnesium - blood Male Selenium - blood Superoxide Dismutase - blood Trace elements Trace Elements - blood Zinc - blood |
| Title | Alterations of plasma magnesium, copper, zinc, iron and selenium concentrations and some related erythrocyte antioxidant enzyme activities in patients with Alzheimer’s disease |
| URI | https://dx.doi.org/10.1016/j.jtemb.2010.02.002 https://www.ncbi.nlm.nih.gov/pubmed/20569929 https://www.proquest.com/docview/733405837 |
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